ARCADE
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 project overview

ARCADE

01/12/2009 - 31/05/2013

FP7-REGPOT-2009-1 Support action

(Grant Agreement Number 245866)


ARCADE is a Regional Potential of Convergence Regions project within the EU FP7 Capacities programme. The project commenced on 01/12/2009 with coordination by the Institute of Organic and Pharmaceutical Chemistry (IOPC), part of the National Hellenic Research Foundation (NHRF) situated in the Convergent Region of Attiki in Greece. ARCADE was initially of 36-months duration but was subsequently extended for a further 6 months. The project finished on 31st May 2013. From March 2012 the IOPC has amalgamated with the Institute of Biological Research and Biotechnology of the NHRF to form a new institute, the Institute of Biology, Medicinal Chemistry and Biotechnology (IBMCB). ARCADE is now being managed by the Division of Organic and Medicinal Chemistry (DOMC) of the new institute. The key concept behind ARCADE is that, in order to strengthen the research profile of the DOMC, and also the IBMCB, and to enable its members to participate effectively in research activities at a Community level of excellence, certain measures need to be taken in order to reinforce the institute's research capability in areas where it has recognised expertise.


 

The ARCADE project, therefore, addresses specific objectives designed to have maximal impact on the DOMC's research activities and to build on the existing expertise in the design, synthesis and analysis of new compounds with potential applications in medicinal chemistry, catalysis and materials science.

 

Click here to learn more about ARCADE

 

 


    

 

Research publication



Dynamic combinatorial chemistry has been used by Mondal et al. to generate a library of potential acylhydrazone inhibitors of the aspartic protease endothiapepsin. The protein-bound library members were characterised by saturation-transfer difference NMR spectroscopy and cocrystallization experiments validated the predicted binding mode of the two most potent inhibitors.(Summary)

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Research publication



Prousis et al. have reported the ultrasound-asisted, catalytic synthesis in excellent yields of coumarin derivatives under solvent-free conditions (Summary)

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Research publication



Martina et al. describe the highly efficient microwave-assisted synthetic decoration of per-substituted β-cyclodextrins together with supporting computational analyses.(Summary)

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